20633690
not annotated - annotated - LINNAEUS only
UreA, the major urea/H+ symporter in Aspergillus nidulans.
We report here the characterization of UreA, a high-affinity urea/H+ symporter of Aspergillus nidulans. The deletion of the encoding gene abolishes urea transport at low substrate concentrations, suggesting that in these conditions UreA is the sole transport system specific for urea in A. nidulans. The ureA gene is not inducible by urea or its precursors, but responds to nitrogen metabolite repression, necessitating for its expression the AreA GATA factor. In contrast to what was observed for other transporters in A. nidulans, repression by ammonium is also operative during the isotropic growth phase. The activity of UreA is down-regulated post-translationally by ammonium-promoted endocytosis. A number of homologues of UreA have been identified in A. nidulans and other Aspergilli, which cluster in four groups, two of which contain the urea transporters characterized so far in fungi and plants. This phylogeny may have arisen by gene duplication events, giving place to putative transport proteins that could have acquired novel, still unidentified functions.
Ann file
T1 Species 37 57 Aspergillus nidulans
N1 Reference T1 Taxonomy:162425
T2 Species 143 163 Aspergillus nidulans
N2 Reference T2 Taxonomy:162425
T3 Species 348 359 A. nidulans
N3 Reference T3 Taxonomy:162425
T4 Species 581 592 A. nidulans
N4 Reference T4 Taxonomy:162425
T5 Species 819 830 A. nidulans
N5 Reference T5 Taxonomy:162425