20735493
not annotated - annotated - LINNAEUS only
Parallel evolution of cytochrome b mediated bifenazate resistance in the citrus red mite Panonychus citri.
Bifenazate is a recently developed acaricide that is mainly used to control spider mites on a variety of crops. Although first thought to be a neurotoxin, genetic evidence obtained from bifenazate resistant Tetranychus urticae strains suggested an alternative mode of action as a Qo pocket inhibitor of the mitochondrial complex III. In this study, we reveal how bifenazate resistance in strains of Panonychus citri is maternally inherited and can confer cross-resistance to the known Qo inhibitor acequinocyl. The mitochondrial genome of P. citri was sequenced and Qo pocket mutations were shown to be linked with the resistant trait. Parallel evolution of cytochrome b mediated bifenazate resistance corroborates the alternative mode of action and yet again illustrates that care should be taken when employing Qo inhibitors as crop protection compounds.
Ann file
T1 Species 73 88 citrus red mite
N1 Reference T1 Taxonomy:50023
T2 Species 89 105 Panonychus citri
N2 Reference T2 Taxonomy:50023
T3 Species 316 335 Tetranychus urticae
N3 Reference T3 Taxonomy:32264
T4 Species 508 524 Panonychus citri
N4 Reference T4 Taxonomy:50023
T5 Species 648 656 P. citri
N5 Reference T5 Taxonomy:50023