20980518
not annotated - annotated - LINNAEUS only
Upregulation of CXCL10 in human dorsal root ganglia during experimental and natural varicella-zoster virus infection.
Varicella-zoster virus (VZV) reactivation causes herpes zoster, which is accompanied by an influx of lymphocytes into affected ganglia, but the stimulus for this infiltrate is not known. We report that VZV infection of ganglia leads to increased CXCL10 production in vitro, in an explant ganglion model and in naturally infected dorsal root ganglia (DRG) during herpes zoster. Lymphocytes expressing the receptor for CXCL10, CXCR3, were also observed throughout naturally infected ganglia during herpes zoster, including immediately adjacent to neurons. This study identifies VZV-induced CXCL10 as a potential driver of T lymphocyte recruitment into DRG during herpes zoster.
Ann file
T1 Species 26 31 human
N1 Reference T1 Taxonomy:9606
T2 Species 84 106 varicella-zoster virus
N2 Reference T2 Taxonomy:10335
T3 Species 144 147 VZV
N3 Reference T3 Taxonomy:10335
T4 Species 322 325 VZV
N4 Reference T4 Taxonomy:10335
T5 Species 696 699 VZV
N5 Reference T5 Taxonomy:10335
T6 Species 120 142 Varicella-zoster virus
N6 Reference T6 Taxonomy:10335 Human alphaherpesvirus 3