20980520
not annotated - annotated - LINNAEUS only
Persistent Friend virus replication and disease in Apobec3-deficient mice expressing functional B-cell-activating factor receptor.
Rfv3 is an autosomal dominant gene that influences the recovery of resistant mice from Friend retrovirus (FV) infection by limiting viremia and promoting a more potent neutralizing antibody response. We previously reported that Rfv3 is encoded by Apobec3, an innate retrovirus restriction factor. However, it was recently suggested that the Rfv3 susceptible phenotype of high viremia at 28 days postinfection (dpi) was more dominantly controlled by the B-cell-activating factor receptor (BAFF-R), a gene that is linked to but located outside the genetically mapped region containing Rfv3. Although one prototypical Rfv3 susceptible mouse strain, A/WySn, indeed contains a dysfunctional BAFF-R, two other Rfv3 susceptible strains, BALB/c and A.BY, express functional BAFF-R genes, determined on the basis of genotyping and B-cell immunophenotyping. Furthermore, transcomplementation studies in (C57BL/6 [B6] x BALB/c)F(1) and (B6 x A.BY)F(1) mice revealed that the B6 Apobec3 gene significantly influences recovery from FV viremia, cellular infection, and disease at 28 dpi. Finally, the Rfv3 phenotypes of prototypic B6, A.BY, A/WySn, and BALB/c mouse strains correlate with reported Apobec3 mRNA expression levels. Overall, these findings argue against the generality of BAFF-R polymorphisms as a dominant mechanism to explain the Rfv3 recovery phenotype and further strengthen the evidence that Apobec3 encodes Rfv3.
Ann file
T1 Species 11 23 Friend virus
N1 Reference T1 Taxonomy:11786
T2 Species 69 73 mice
N2 Reference T2 Taxonomy:10090
T3 Species 210 214 mice
N3 Reference T3 Taxonomy:10090
T4 Species 220 237 Friend retrovirus
N4 Reference T4 Taxonomy:11786
T5 Species 239 241 FV
N5 Reference T5 Taxonomy:11786
T6 Species 765 770 mouse
N6 Reference T6 Taxonomy:10090
T7 Species 1074 1078 mice
N7 Reference T7 Taxonomy:10090
T8 Species 1152 1154 FV
N8 Reference T8 Taxonomy:11786
T9 Species 1279 1284 mouse
N9 Reference T9 Taxonomy:10090