21047954
not annotated - annotated - LINNAEUS only
Complement opsonization enhances friend virus infection of B cells and thereby amplifies the virus-specific CD8+ T cell response.
B cells are one of the targets of Friend virus (FV) infection, a well-established mouse model often used to study retroviral infections in vivo. Although B cells may be effective in stimulating cytotoxic T lymphocyte responses, studies involving their role in FV infection have mainly focused on neutralizing antibody production. Here we show that polyclonal activation of B cells promotes their infection with FV both in vitro and in vivo. Furthermore, we demonstrate that complement opsonization of Friend murine leukemia virus (F-MuLV) enhances infection of B cells, which correlates with increased potency of B cells to activate FV-specific CD8(+) T cells.
Ann file
T1 Species 246 256 retroviral
N1 Reference T1 Taxonomy:31931
T2 Species 640 670 murine leukemia virus (F-MuLV)
N2 Reference T2 Taxonomy:11786
T3 Species 214 219 mouse
T4 Species 33 45 friend virus
N3 Reference T4 Taxonomy:11786
T5 Species 166 178 Friend virus
N4 Reference T5 Taxonomy:11786
T6 Species 180 182 FV
N5 Reference T6 Taxonomy:11786
N6 Reference T3 Taxonomy:10090 Mus musculus
#1 AnnotatorNotes T1 TODO check
#2 AnnotatorNotes T2 TODO check
T7 Species 392 394 FV
N7 Reference T7 Taxonomy:11786
T8 Species 543 545 FV
N8 Reference T8 Taxonomy:11786