21097608
not annotated - annotated - LINNAEUS only
African 2, a clonal complex of Mycobacterium bovis epidemiologically important in East Africa.
We have identified a clonal complex of Mycobacterium bovis isolated at high frequency from cattle in Uganda, Burundi, Tanzania, and Ethiopia. We have named this related group of M. bovis strains the African 2 (Af2) clonal complex of M. bovis. Af2 strains are defined by a specific chromosomal deletion (RDAf2) and can be identified by the absence of spacers 3 to 7 in their spoligotype patterns. Deletion analysis of M. bovis isolates from Algeria, Mali, Chad, Nigeria, Cameroon, South Africa, and Mozambique did not identify any strains of the Af2 clonal complex, suggesting that this clonal complex of M. bovis is localized in East Africa. The specific spoligotype pattern of the Af2 clonal complex was rarely identified among isolates from outside Africa, and the few isolates that were found and tested were intact at the RDAf2 locus. We conclude that the Af2 clonal complex is localized to cattle in East Africa. We found that strains of the Af2 clonal complex of M. bovis have, in general, four or more copies of the insertion sequence IS6110, in contrast to the majority of M. bovis strains isolated from cattle, which are thought to carry only one or a few copies.
Ann file
T1 Species 31 50 Mycobacterium bovis
N1 Reference T1 Taxonomy:1765
T2 Species 136 155 Mycobacterium bovis
N2 Reference T2 Taxonomy:1765
T3 Species 188 194 cattle
N3 Reference T3 Taxonomy:9913
T4 Species 275 283 M. bovis
N4 Reference T4 Taxonomy:1765
T5 Species 330 338 M. bovis
N5 Reference T5 Taxonomy:1765
T6 Species 514 522 M. bovis
N6 Reference T6 Taxonomy:1765
T7 Species 701 709 M. bovis
N7 Reference T7 Taxonomy:1765
T8 Species 992 998 cattle
N8 Reference T8 Taxonomy:9913
T9 Species 1066 1074 M. bovis
N9 Reference T9 Taxonomy:1765
T10 Species 1178 1186 M. bovis
N10 Reference T10 Taxonomy:1765
T11 Species 1209 1215 cattle
N11 Reference T11 Taxonomy:9913