21131495
not annotated - annotated - LINNAEUS only
Complete genome sequence of Burkholderia rhizoxinica, an Endosymbiont of Rhizopus microsporus.
Burkholderia rhizoxinica is an intracellular symbiont of the phytopathogenic fungus Rhizopus microsporus. The vertically transmitted endosymbiont not only delivers the antimitotic macrolide rhizoxin to its host but is also essential for vegetative spore formation of the fungus. To shed light on the genetic equipment of this model organism, we sequenced the whole genome of B. rhizoxinica HKI 0454, thus providing the first genomic insight into an intracellular mutualist of a fungal species. The 3.75-Mb genome consists of a chromosome and two strain-specific plasmids. The primary metabolism appears to be specialized for the uptake of fungal metabolites. Besides the rhizoxin biosynthesis gene cluster, there are 14 loci coding for nonribosomal peptide synthetase (NRPS) assembly lines, which represent novel targets for genomic mining of cryptic natural products. Furthermore, the endosymbionts are equipped with a repertoire of virulence-related factors, which can now be studied to elucidate molecular mechanisms underlying bacterial-fungal interaction.
Ann file
T1 Species 28 52 Burkholderia rhizoxinica
N1 Reference T1 Taxonomy:412963
T2 Species 73 93 Rhizopus microsporus
N2 Reference T2 Taxonomy:58291
T3 Species 97 121 Burkholderia rhizoxinica
N3 Reference T3 Taxonomy:412963
T4 Species 181 201 Rhizopus microsporus
N4 Reference T4 Taxonomy:58291
T5 Species 472 495 B. rhizoxinica HKI 0454
N5 Reference T5 Taxonomy:882378 Paraburkholderia rhizoxinica HKI 454