21199020
not annotated - annotated - LINNAEUS only
Genetic analysis of the xenobiotic resistance-associated ABC gene subfamilies of the Lepidoptera.
Some ATP-binding cassette (ABC) transporters of subfamilies B, C and G confer resistance to xenobiotics including insecticides. We identified genes of these subfamilies expressed by the lepidopterans Trichoplusia ni and Bombyx mori. The B. mori genome includes eight, six and 13 ABC-B, -C and -G genes, respectively, which encode P-glycoprotein, multidrug resistance protein, MRP, and breast cancer resistance protein, BCRP, homologues. Among the ABC-C and -G subfamilies, gene duplication contributes to protein diversity. We have identified three ABC-B and two ABC-C T. ni genes. Analyses of the T. ni MRP (TrnMRP) revealed unique features, including the potential for TrnMRP4 hyperglycosylation and the alternative splicing of TrnMRP1. Taken together, these attributes of moth multidrug resistance-associated ABCs may confer distinct functional capacities to xenobiotic efflux.
Ann file
T1 Species 300 315 Trichoplusia ni
N1 Reference T1 Taxonomy:7111
T2 Species 320 331 Bombyx mori
N2 Reference T2 Taxonomy:7091
T3 Species 337 344 B. mori
N3 Reference T3 Taxonomy:7091
T4 Species 669 674 T. ni
N4 Reference T4 Taxonomy:7111
T5 Species 698 703 T. ni
N5 Reference T5 Taxonomy:7111