21459211
not annotated - annotated - LINNAEUS only
Increasing burden of liver disease in patients with HIV infection.
Introduction of effective combined antiretroviral therapy has made HIV infection a chronic illness. Substantial reductions in the number of AIDS-related deaths have been accompanied by an increase in liver-related morbidity and mortality due to co-infection with chronic hepatitis B and C viruses. Increases in non-alcoholic fatty liver disease and drug-induced hepatotoxicity, together with development of hepatocellular carcinoma, also potentiate the burden of liver disease in individuals with HIV infection. We provide an overview of the key causes, disease mechanisms of pathogenesis, and recommendations for treatment options including the evolving role of liver transplantation.
Ann file
T1 Species 52 55 HIV
N1 Reference T1 Taxonomy:12721 Human immunodeficiency virus
#1 AnnotatorNotes T1 TODO check
T2 Species 565 568 HIV
N2 Reference T2 Taxonomy:12721 Human immunodeficiency virus
#2 AnnotatorNotes T2 TODO check
T3 Species 339 364 hepatitis B and C viruses
#3 AnnotatorNotes T3 TODO
T4 Species 135 138 HIV
N3 Reference T4 Taxonomy:12721 Human immunodeficiency virus