21511047
not annotated - annotated - LINNAEUS only
Milestones in Candida albicans gene manipulation.
In the United States, candidemia is one of the most common hospital-acquired infections and is estimated to cause 10,000 deaths per year. The species Candida albicans is responsible for the majority of these cases. As C. albicans is capable of developing resistance against the currently available drugs, understanding the molecular basis of drug resistance, finding new cellular targets, and further understanding the overall mechanism of C. albicans pathogenesis are important goals. To study this pathogen it is advantageous to manipulate its genome. Numerous strategies of C. albicans gene manipulation have been introduced. This review evaluates a majority of these strategies and should be a helpful guide for researchers to identify gene targeting strategies to suit their requirements.
Ann file
T1 Species 14 30 Candida albicans
N1 Reference T1 Taxonomy:5476
T2 Species 201 217 Candida albicans
N2 Reference T2 Taxonomy:5476
T3 Species 269 280 C. albicans
N3 Reference T3 Taxonomy:5476
T4 Species 491 502 C. albicans
N4 Reference T4 Taxonomy:5476
T5 Species 628 639 C. albicans
N5 Reference T5 Taxonomy:5476