21511329
not annotated - annotated - LINNAEUS only
Hepatitis delta virus.
Hepatitis delta virus (HDV) is a small, defective RNA virus that can infect only individuals who have hepatitis B virus (HBV); worldwide more than 15 million people are co-infected. There are eight reported genotypes of HDV with unexplained variations in their geographical distribution and pathogenicity. The hepatitis D virion is composed of a coat of HBV envelope proteins surrounding the nucleocapsid, which consists of a single-stranded, circular RNA genome complexed with delta antigen, the viral protein. HDV is clinically important because although it suppresses HBV replication, it causes severe liver disease with rapid progression to cirrhosis and hepatic decompensation. The range of clinical presentation is wide, varying from mild disease to fulminant liver failure. The prevalence of HDV is declining in some endemic areas but increasing in northern and central Europe because of immigration. Treatment of HDV is with pegylated interferon alfa; however, response rates are poor. Increased understanding of the molecular virology of HDV will identify novel therapeutic targets for this most severe form of chronic viral hepatitis.
Ann file
T1 Species 0 21 Hepatitis delta virus
N1 Reference T1 Taxonomy:12475
T2 Species 24 45 Hepatitis delta virus
N2 Reference T2 Taxonomy:12475
T3 Species 47 50 HDV
N3 Reference T3 Taxonomy:12475
T4 Species 126 143 hepatitis B virus
N4 Reference T4 Taxonomy:10407
T5 Species 145 148 HBV
N5 Reference T5 Taxonomy:10407
T6 Species 244 247 HDV
N6 Reference T6 Taxonomy:12475
T7 Species 334 345 hepatitis D
N7 Reference T7 Taxonomy:12475
T8 Species 378 381 HBV
N8 Reference T8 Taxonomy:10407
T9 Species 536 539 HDV
N9 Reference T9 Taxonomy:12475
T10 Species 595 598 HBV
N10 Reference T10 Taxonomy:10407
T11 Species 823 826 HDV
N11 Reference T11 Taxonomy:12475
T12 Species 945 948 HDV
N12 Reference T12 Taxonomy:12475
T13 Species 1071 1074 HDV
N13 Reference T13 Taxonomy:12475