21815956
not annotated - annotated - LINNAEUS only
Insertion of an intact CR1 retrotransposon in a cadherin gene linked with Bt resistance in the pink bollworm, Pectinophora gossypiella.
Three mutations in the Pectinophora gossypiella cadherin gene PgCad1 are linked with resistance to Bacillus thuringiensis (Bt) toxin Cry1Ac. Here we show that the r3 mutation entails recent insertion into PgCad1 of an active chicken repeat (CR1) retrotransposon, designated CR1-1_Pg. Unlike most other CR1 elements, CR1-1_Pg is intact, transcribed by a flanking promoter, contains target site duplications and has a relatively low number of copies. Examination of transcripts from the PgCad1 locus revealed that CR1-1_Pg disrupts both the cadherin protein and a long noncoding RNA of unknown function. Together with previously reported data, these findings show that transposable elements disrupt eight of 12 cadherin alleles linked with resistance to Cry1Ac in three lepidopteran species, indicating that the cadherin locus is a common target for disruption by transposable elements.
Ann file
T1 Species 95 108 pink bollworm
N1 Reference T1 Taxonomy:13191
T2 Species 110 134 Pectinophora gossypiella
N2 Reference T2 Taxonomy:13191
T3 Species 161 185 Pectinophora gossypiella
N3 Reference T3 Taxonomy:13191
T4 Species 237 259 Bacillus thuringiensis
N4 Reference T4 Taxonomy:1428
T5 Species 261 263 Bt
N5 Reference T5 Taxonomy:1428
T6 Species 363 370 chicken
N6 Reference T6 Taxonomy:9031
#1 AnnotatorNotes T6 TODO check
T7 Species 74 76 Bt
N7 Reference T7 Taxonomy:1428